Primary Biliary Cholangitis

About the Disease
Primary Biliary Cholangitis, also known as primary biliary cirrhosis, is related to gastrointestinal system disease and non-alcoholic fatty liver disease. An important gene associated with Primary Biliary Cholangitis is PBC2 (Biliary Cirrhosis, Primary, 2), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Cell differentiation - expanded index. The drugs Abatacept and Meropenem have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, liver and bone, and related phenotypes are cirrhosis and biliary cirrhosis

Common Targets
PUS10 | RPS6KA4 | GPBAR1 | CLCNKA | IL21-AS1 | TTC27 | LOC105372988 | SLC22A1 | CD3 Complex (T Cell Receptor Complex) | FUNDC2 | HORMAD2 | PDE4B | TNPO3 | PPARA | CYP7A1 | HLA-B | TMEM39A | G4780 | UBE2A | OR52B2 | TYK2 | TRAF3 | FAM110D | PNPLA3 | LOC105377551 | CD58 | KCNH5 | HLA-DRB1 | TPMT | HLA-DQA1 | LYVE1 | RUNX3 | CTSS | BMX | DLAT | BRD4 | SIGLEC8 | PIK3CD | EPS8L1 | PPARG | CTNNA2 | CTSL | PLCL2 | CLN3 | CASP10 | CSF3R | G7124 | PLCL1 | PRKRIP1 | NOTCH4 | SCNN1D | NOX4 | SEZ6L | S1PR4 | HSD11B1 | IQCN | NUDT15 | GABA(A) receptor | ZNF614 | HLA-A | CD40 | ZSCAN5B | UBE2L3 | PPARD | ELP1 | G3605 | SERPINA7 | MMEL1 | LACC1 | G4137 | CD244 | SHC1 | NR3C1 | CCDC113 | ACHE | ULK4 | DCHS1 | G3480 | GIPR | HLA-DRA | FCRL3 | OBSL1 | ITGA11 | IL12RB2 | G3630 | Interleukin-12 (IL-12) | SLC22A23 | LILRA1 | EPG5 | USP2 | GCKR | DENND1B | PIK3CA | SYNGR1 | ELMO1 | ZGPAT | NR1H4 | ADORA3 | TIMMDC1 | C1orf94 | G4233 | CCNY | MS4A1 | VDR | CXCR3 | Vascular endothelial growth factor receptor (VEGFR) (nonspecified subtype) | HIVEP2 | CTLA4 | NADSYN1 | LINC02513 | WHAMM | STAT4 | ARID3A | LOC285626 | CHIA | CD80 | IL10 | OR8G5 | IKZF3 | ELF1 | PRKCB | BTG4 | CLEC16A | TLR9 | MED4 | IL16 | Integrin alphavbeta6 receptor | S1PR5 | IL12A | PAPPA | APOA1 | NOX1 | ZNF865 | CXCL10 | SLC10A2 | IL12A-AS1 | CREBBP | SPIB | HLA-DPB1 | TNFSF15 | LINC01100 | HNF4A | CLDN14 | CTSB | OR52W1 | Integrin alphavbeta1 | ABCB11 | SH2B3 | TRIM32 | SRSF12 | FER1L6 | JAK1 | JAK2 | MANBA | Vascular endothelial growth factors (VEGF) (nonspecified subtype) | CTNNB1 | ZNF683 | TNFRSF1A | GLP1R | ACACA | HLA-DQB1 | EXOC3L4 | TEAD1 | FGF2 | PIK3CG | PPARGC1A | USP37 | MRGPRX4 | GPR65 | PER3 | HECW2 | RELN | Interleukin 23 complex (IL-23) | CAPSL | LOC105379031 | NF-kappaB (NFkB) | G6774 | UMAD1 | CMA1 | ZMIZ1 | RAD51B | G6647 | NFKB1 | DKK2 | IL21R | GCGR | ZNF292 | FCRL4 | TNFSF4 | LOC105377139 | Phosphodiesterase (nonspecified subtype) | POLD1 | IL12B | URM1 | BTK | FGFR2 | NCOR1 | CX3CL1 | LOC101927745

Note: If you'd like to get a target analysis report for Primary Biliary Cholangitis, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Primary Biliary Cholangitis at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

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