Huntington's Disease-like 2
Huntington's Disease-like 2
About the Disease
Huntington Disease-Like 2, also known as hdl2, is related to neuroacanthocytosis and huntington disease-like 1, and has symptoms including muscle rigidity, bradykinesia and action tremor. An important gene associated with Huntington Disease-Like 2 is JPH3 (Junctophilin 3). The drugs Lipid Regulating Agents and Rosuvastatin Calcium have been mentioned in the context of this disorder. Affiliated tissues include caudate nucleus, heart and liver, and related phenotypes are personality changes and hyperreflexia
Common Targets
JPH3
![疾病靶点研报](../img/disease-target-analysis-report.jpg)
Note: If you'd like to get a target analysis report for Huntington's Disease-like 2, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Huntington's Disease-like 2 at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.
Other Diseases
Nasodigitoacoustic Syndrome | Usher Syndrome Type IIC | Anorexia Nervosa | Keratitis | Syphilis | Cholecystitis | Chronic Neutrophilic Leukemia | Methylmalonic Acidemia | Triple A Syndrome | Blepharospasm | Otitis Externa | Atelosteogenesis Type 1 | Pyruvate Dehydrogenase Deficiency | Atopic Dermatitis | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Hereditary Mixed Polyposis Syndrome | X-linked Myotubular Myopathy | Plasma Cell Leukemia | Nestor-Guillermo Progeria Syndrome | Carotid Artery Disease | Nicotine Addiction | Antithrombin III Deficiency | B-cell Chronic Lymphocytic Leukemia | Tuberculous Meningitis | Cerebrotendinous Xanthomatosis | Tetraplegia | Schuurs-Hoeijmakers Syndrome | Galactosemia | Wiskott-Aldrich Syndrome | Microvillus Inclusion Disease | Pemphigus Vulgaris | Stuve-Wiedemann Syndrome | Crimean-Congo Hemorrhagic Fever | Osteochondrosis | Congenital Bile Acid Synthesis Defect | Cystinuria | Oguchi Disease-2 | Mycosis Fungoides | Dermatomyositis | Spinal Muscular Atrophy | Chondroma | Micropenis | Hyperinsulinemia | Ureteropelvic Junction Obstruction | Anxiety Disorders | Neurofibromatosis Type 2 | Hyperphenylalaninemia | Graft-versus-host Disease | Erectile Dysfunction | Neuropathy | Alpha-thalassemia Myelodysplasia Syndrome | Hypoglycemia | Niemann-Pick Disease, Type A | Neurodegeneration With Brain Iron Accumulation | Schizencephaly | Amelogenesis Imperfecta | Ellis-Van Creveld Syndrome | Hemophagocytic Lymphohistiocytosis | Ovarian Hyperstimulation Syndrome | Patent Foramen Ovale | Loeys-Dietz Syndrome | Congenital Torticollis | Waardenburg Syndrome Type 2A | Vascular Calcification | Combined Malonic And Methylmalonic Acidemia | Inflammatory Myopathy | Periodontitis | Keratopathy | MELAS Syndrome | Methylmalonic Aciduria And Homocystinuria, CblC Type | Premature Ejaculation | Malignant Peripheral Nerve Sheath Tumor | Chronic Periodontitis | Erythematotelangiectatic Rosacea | Angiomyolipoma | Fibromyalgia | Oculocutaneous Albinism Type 1 | Osteogenesis Imperfecta Type I | Familial Hyperaldosteronism | Plasma Cell Dyscrasia | Hypercalcemia | Megalencephaly | Tracheal Disorders | Hydrocephalus | Sarcoma, Ewing | Gastritis | Focal Segmental Glomerulosclerosis | Thrombocythemia, Essential | Measles | Epidermolytic Hyperkeratosis | Wolcott-Rallison Syndrome | Hypopituitarism | Primary Sclerosing Cholangitis | Johanson-Blizzard Syndrome | Primary Lateral Sclerosis | Fragile X Syndrome | Polyneuropathy | Sulfite Oxidase Deficiency | Conjunctivitis | Leukocyte Adhesion Deficiency | Personality Disorders | Syncope | Eclampsia | Spinocerebellar Ataxia Type 15 | Congenital Dyserythropoietic Anemia | Myofibromatosis | Choroiditis | Mevalonate Kinase Deficiency | Esophagitis | Atelosteogenesis Type 2 | Seizures-scoliosis-macrocephaly Syndrome | Crouzon Syndrome With Acanthosis Nigricans | Cannabis Abuse | Hereditary Sensory Neuropathy Type 1 | Microcephalic Osteodysplastic Primordial Dwarfism, Type I | Pfeiffer Syndrome | Schaaf-Yang Syndrome | Ulcerative Colitis | Exfoliative Dermatitis | IgA Deficiency | Acrodermatitis Enteropathica | Congenital Disorders Of Glycosylation Type II | Wiedemann-Steiner Syndrome | Sitosterolemia | Early Infantile Epileptic Encephalopathy 28 | Impetigo | Duane Retraction Syndrome | Paraplegia | Leber Congenital Amaurosis | Spina Bifida | Takotsubo Cardiomyopathy | Epidermal Nevus Syndrome | Cri-du-chat Syndrome | Charcot-Marie-Tooth Disease, Type 6 | Trigonocephaly | Pulmonary Tuberculosis | Colitis, Lymphocytic | Pemphigus Foliaceus | Familial Pheochromocytoma-paraganglioma | Erythema Multiforme | Venous Insufficiency | Achondrogenesis | Multiple Mitochondrial Dysfunctions Syndrome Type 1 | Lymphomatoid Granulomatosis | Pancreatitis | N-acetylglutamate Synthase Deficiency | Temtamy Preaxial Brachydactyly Syndrome | Chondrodysplasia Punctata | Lamellar Ichthyosis | Hidradenitis | Agranulocytosis | Asthma | Cavitary Optic Disc Anomalies | Cholestasis, Intrahepatic | Turner's Syndrome | Mast Cell Leukemia | Proximal Symphalangism | Motor Neuron Diseases | Congenital Adrenal Hyperplasia 1 | Insulin Resistance | Bronchitis, Chronic | Dysferlinopathy | Blau Syndrome | Reye Syndrome | Barrett Esophagus | Chromosome 8q21.11 Deletion Syndrome | Spondylo-ocular Syndrome | Hyper IgE Syndrome | Phosphoglycerate Dehydrogenase Deficiency | Neurotoxicity | DiGeorge Syndrome | Aneurysm, Thoracic Aortic | LEOPARD Syndrome | Multiple Myeloma | Osteoglophonic Dysplasia | DRESS Syndrome | Carcinoma, Merkel Cell | Thrombophilia | Gray Platelet Syndrome | Duchenne Muscular Dystrophy | Takenouchi-Kosaki Syndrome | Imerslund-Grasbeck Syndrome | Cancer, Colon | Combined Deficiency Of Factor V And Factor VIII | Tendinopathy | Cardiac Sarcoidosis | Polymicrogyria | Fatty Aldehyde Dehydrogenase Deficiency | Congenital Hemolytic Anemia | Leprosy | Acromesomelic Dysplasia | Subacute Sclerosing Panencephalitis | IMAGe Syndrome | Blue Rubber Bleb Nevus Syndrome | Tumoral Calcinosis | Pyloric Stenosis, Infantile Hypertrophic | Gynecomastia | Echinococcosis | Gallstones | Epidermolysis Bullosa | Lassa Fever | Carcinoid Tumor | Congenital Stromal Corneal Dystrophy | Mitochondrial Myopathy | Follicular Dendritic Cell Sarcoma | Schizophrenia | Hyperammonemia | Osteomyelitis | Melanoma, Uveal | Mitochondrial Cytopathy | Axenfeld-Rieger Syndrome | Vascular Cognitive Impairment | Ocular Surface Squamous Neoplasia | Lattice Corneal Dystrophy Type 1 | Yellow Fever | Coenzyme Q10 Deficiency | Alcoholism | Trichuriasis | Stevens-Johnson Syndrome | Schistosomiasis | Lymphoproliferative Disorders | Medulloblastoma | 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Aicardi-Goutieres Syndrome | Encephalopathy, Hepatic | Juvenile Myelomonocytic Leukemia | Pre-eclampsia | Peutz-Jeghers Syndrome | Deafness, Dystonia, And Cerebral Hypomyelination | Heavy Chain Disease | Epiphyseal Chondrodysplasia, Miura Type | Neurofibromatosis Type 1 | Kindler Syndrome | Diabetes Type 2 | Liver Failure, Acute Infantile | Thalassemia, Beta | Persistent Mullerian Duct Syndrome | Primary Progressive Aphasia | Partington Syndrome | Schindler Disease | Polycystic Kidney, Autosomal Dominant | Chronic Idiopathic Myelofibrosis | Myopathy | Zellweger Syndrome | Hypertension | Mandibuloacral Dysplasia With Type A Lipodystrophy | Dysmorphophobia | Coronary Restenosis | Withdrawal Syndrome | Parapsoriasis | Harlequin Ichthyosis | Gastritis, Atrophic | Eosinophilic Asthma | Heart Block | Craniolenticulosutural Dysplasia | Melanocytic Nevus | Birk-Barel Syndrome | Coffin-Lowry Syndrome | Hypoalbuminemia | Muir-Torre Syndrome | Hypoplastic Left Heart Syndrome | Allergic Contact Dermatitis | Alstrom Syndrome | Cocaine-Related Disorders | Familial Glucocorticoid Deficiency | Amblyopia | Charcot-Marie-Tooth Disease, Type 1A | Rubeosis Iridis | Currarino Syndrome | HELLP Syndrome | Spinocerebellar Ataxia Type 7 | Rotor Syndrome | Synovitis | Hemochromatosis Type 1 | Conjunctivitis, Allergic | 3C Syndrome | Inflammatory Linear Verrucous Epidermal Nevus | Huntington's Disease | Protein C Deficiency | Mitochondrial Disease | Congenital Dysfibrinogenemia | Chiari Malformation Type I | Pseudohypoparathyroidism Type 1B | Antiphospholipid Syndrome | Paget's Disease Of The Breast | Paraganglioma | Osmotic Demyelination Syndrome | Facioscapulohumeral Muscular Dystrophy Type 2 | Swine Influenza | Usher Syndrome Type II | Pulmonary Veno-occlusive Disease | Hepatitis, Alcoholic | Dementia, Vascular | Cleidocranial Dysplasia | Retinal Detachment | MIRAGE Syndrome | Hyperparathyroidism-jaw Tumor Syndrome | Myhre Syndrome | Protein S Deficiency | Stargardt Disease | Acne | Acromegaly | Blue Nevus | Nutrition Disorders | Mumps | Tyrosinemia | Omenn Syndrome | Heroin Dependence | Juvenile Myoclonic Epilepsy | CDKL5 Deficiency Disorder | Antenatal Bartter Syndrome Type 1 | Lymphangioleiomyomatosis | Adams-Oliver Syndrome | Chediak-Higashi Syndrome | Thyroid Dysgenesis | Non-Langerhans Cell Histiocytosis | Oligospermia | Gilbert Syndrome | Smith-Lemli-Opitz Syndrome | Non-small Cell Lung Cancer | Infantile Liver Failure Syndrome 1 | Schwannoma | Hernia, Inguinal | Chronic Myeloid Leukemia | Lateral Meningocele Syndrome | Craniofrontonasal Syndrome | Spinocerebellar Ataxia Type 8 | Cutaneous Lupus Erythematosus | Lymphangioma | Cholangiocarcinoma | Epidermolytic Ichthyosis, Annular | Leukoplakia, Oral | Stuttering | Cellulitis | Double Outlet Right Ventricle | Precocious Puberty | Veno-occlusive Disease | Senior-Loken Syndrome | Hemimegalencephaly | Gestational Trophoblastic Disease | Mannosidase Deficiency Diseases | Optic Neuropathy, Anterior Ischemic | Colitis | Mabry Syndrome | Proopiomelanocortin Deficiency | Rift Valley Fever | Glioma | Pseudo-pseudohypoparathyroidism | Farber Disease | Odonto-onycho-dermal Dysplasia | Batten Disease | Giant Cell Glioblastoma | Progressive Familial Intrahepatic Cholestasis Type 3 | Dwarfism | Lafora Disease | Hereditary Hemorrhagic Telangiectasia Type 2 | Esophageal Motility Disorders | Adenocarcinoma | Seizures | Retinal Telangiectasia | Angioedema | Vaginitis | Nemaline Myopathy 8 | Myosin Storage Myopathy | Mitochondrial Encephalomyopathy | Porphyria, Acute Intermittent | Rheumatoid Arthritis | Microtia | Leber Hereditary Optic Neuropathy | Knobloch Syndrome | Blood Protein Disorders | Fabry's Disease | Pierpont Syndrome | Neurofibromatosis-Noonan Syndrome | Congenital Fiber-type Disproportion Myopathy | Lissencephaly 2 | Spondylolisthesis | Marshall-Smith Syndrome | Birt-Hogg-Dube Syndrome | Erdheim-Chester Disease | Neurofibromatosis | Toxoplasmosis | Cystinosis | Platyspondylic Lethal Skeletal Dysplasia, Torrance Type | Osteoarthritis | Carpenter Syndrome | Metachondromatosis | Neurocysticercosis | Melnick-Needles Syndrome | Oligodendroglioma | Acute Motor Axonal Neuropathy | Photosensitivity | Mucolipidosis Type II | Optic Nerve Hypoplasia, Bilateral | Hemolytic Uremic Syndrome | Hartnup Disease | Spinocerebellar Ataxia Type 40 | Rash | Amenorrhea | Pulverulent Zonular Cataract