Pleomorphic Xanthoastrocytoma

About the Disease
Pleomorphic Xanthoastrocytoma, also known as pxa, is related to glioma susceptibility 1 and malignant astrocytoma, and has symptoms including seizures An important gene associated with Pleomorphic Xanthoastrocytoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are "Cell Cycle, Mitotic" and Prolactin Signaling. The drugs Dabrafenib and Trametinib have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and temporal lobe, and related phenotypes are neoplasm and normal

Common Targets
RPTOR | NOTCH3 | FANCD2 | ETV4 | CSF1R | RARA | RAD52 | CHEK1 | NUP93 | CDK4 | G673 | CDKN2B | TRRAP | PPP2R1A | G1029 | G4851 | PDGFRB | ARID2 | NOTCH4 | ROS1 | XPO1 | TBX3 | FLT4 | G7157 | GATA2 | G999 | SMARCA4 | MRE11 | GSK3B | MEN1 | FANCI | RAF1 | G2033 | FGFR4 | FGF19 | FGF23 | CCNE1 | G4233 | DOT1L | VCP | PBRM1 | NF1 | FANCA | RUNX1 | MGMT | LRP1B | NOTCH2 | PARP4 | ARID1A | G2146 | G3845 | MSH6 | PIK3CG | RNF43 | G472 | KDM5A | FANCM | MED12

Note: If you'd like to get a target analysis report for Pleomorphic Xanthoastrocytoma, or if you are interested to learn how our AI-powered BDE-Chem can design therapeutic molecules to interact with the target(s) above against the disease of Pleomorphic Xanthoastrocytoma at a cost 90% lower than traditional approaches, please feel free to contact us at BD@silexon.ai.

Other Diseases

Pseudohypoaldosteronism | Charcot-Marie-Tooth Disease Type 2E | Oligoastrocytoma | Brachial Plexus Neuropathy | Chronic Mucocutaneous Candidiasis | Liddle Syndrome | Hemolytic Uremic Syndrome | Sickle Cell Anemia | Cold-induced Sweating Syndrome | Antisynthetase Syndrome | Odonto-onycho-dermal Dysplasia | Cholangiocarcinoma | Dyslexia | Lewy Body Dementia | Hepatitis E | Diabetic Macular Edema | Alpha-mannosidosis | Cryptococcal Meningitis | Ventricular Septal Defect | Methylmalonic Acidemia | Nicotine Addiction | Traboulsi Syndrome | Neurofibromatosis | Prolidase Deficiency | Turner's Syndrome | Trachoma | Seasonal Mood Disorder | GAPO Syndrome | Beare-Stevenson Syndrome | Gastric Atrophy | Lymphedema-distichiasis Syndrome | Bartter Syndrome | Spinocerebellar Ataxia Type 12 | Loeys-Dietz Syndrome Type 4 | Rolandic Epilepsy | Sarcomatoid Carcinoma Of The Lung | Kashin-Beck Disease | Apraxia | Myoclonus | Corneal Edema | Hypertrophy | Chanarin-Dorfman Syndrome | Kawasaki Disease | Low Tension Glaucoma | Combined Pituitary Hormone Deficiency | Genee-Wiedemann Syndrome | Cysticercosis | Chorea | Corneal Dystrophy And Perceptive Deafness | Osteonecrosis Of The Jaw | Episodic Ataxia | Idiopathic Pulmonary Fibrosis | Takenouchi-Kosaki Syndrome | Anterior Segment Dysgenesis | Multiple Myeloma | Basal Ganglia Cerebrovascular Disease | Isobutyryl-CoA Dehydrogenase Deficiency | CHOPS Syndrome | Genitopatellar Syndrome | Moyamoya Disease | Hypospadias | Mevalonate Kinase Deficiency | Obesity, Morbid | Muscular Dystrophy | Congenital Poikiloderma | Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis | Stuttering | Fibromuscular Dysplasia | Chondrosarcoma | Melanoma | Leber Hereditary Optic Neuropathy | Hypertension, Renal | Primary Sclerosing Cholangitis | Kernicterus | Hypertension, Portal | Papillon-Lefevre Syndrome | GM2-gangliosidosis AB Variant | Azoospermia | Congenital Adrenal Hyperplasia 1 | Cutaneous Mastocytosis | Hypogonadism | Treacher Collins Syndrome | Unverricht-Lundborg Syndrome | Neurocutaneous Syndromes | Cerebrotendinous Xanthomatosis | Blau Syndrome | Otosclerosis | Non-epidermolytic Palmoplantar Keratoderma | Craniopharyngioma | Arthrogryposis | Carney-Stratakis Syndrome | Neuronal Ceroid Lipofuscinosis | Phenylketonuria II | Atelosteogenesis Type 1 | Asthma, Exercise-induced | Primary Biliary Cholangitis | Greig Cephalopolysyndactyly Syndrome | Sleep Apnea, Obstructive | Borderline Personality Disorder | Neurofibroma | Triphalangeal Thumb-polysyndactyly Syndrome | Reye Syndrome | Okihiro Syndrome | Optic Nerve Hypoplasia, Bilateral | Ameloblastic Carcinoma | Aspergillosis | Bainbridge-Ropers Syndrome | Progressive Myoclonic Epilepsy | Presbyopia | Diabetes Type 2 | Dystrophy, Cone-rod | Goiter, Nodular | Bleeding Disorder Due To CalDAG-GEFI Deficiency | Charcot-Marie-Tooth Disease, Type 6 | Deafness, Dystonia, And Cerebral Hypomyelination | Conjunctivitis, Allergic | Meniere's Disease | Jawad Syndrome | Joubert Syndrome 2 | Frontometaphyseal Dysplasia | Infantile Nephropathic Cystinosis | Vitiligo | Erythropoietic Protoporphyria | Non-bullous Congenital Ichthyosiform Erythroderma | Exotropia | Bipolar Disorder | Stomatitis | KBG Syndrome | Hepatopulmonary Syndrome | Charcot-Marie-Tooth Disease Axonal Type 2N | Chondrodysplasia Punctata 2, X-linked Dominant | Rhabdoid Tumor | Glioblastoma | Scabies | Choriocarcinoma | Vogt-Koyanagi-Harada Syndrome | Charcot-Marie-Tooth Disease | Small Lymphocytic Lymphoma | Pre-eclampsia | Spitz Nevus | Amyotrophic Lateral Sclerosis, Juvenile | Presbycusis | Pneumococcal Meningitis | Castleman Disease | Porphyria | Diabetic Encephalopathy | Polyneuropathy | Lymphomatoid Granulomatosis | Pancreatitis, Chronic | Neural Tube Defect | Methylmalonic Aciduria And Homocystinuria, CblC Type | Clouston Hidrotic Ectodermal Dysplasia | Pernicious Anemia | Hypertriglyceridemia | Malaria | Macrophage Activation Syndrome | Abetalipoproteinemia | Osteopathia Striata With Cranial Sclerosis | Membranous Nephropathy | Colitis, Microscopic | Parvovirus B19 Infection | Vitamin D Deficiency | Retinal Dystrophy, Early-onset Severe | Connective Tissue Disorders | Precocious Puberty | Medulloblastoma | Primary Ovarian Insufficiency | Sarcoidosis | Cavitary Optic Disc Anomalies | Arthritis | Blue Nevus | Nijmegen Breakage Syndrome | Inborn Errors Of Metabolism | ACTH-independent Macronodular Adrenal Hyperplasia | Cutaneous Lupus Erythematosus | Adams-Oliver Syndrome | Coffin-Lowry Syndrome | Leukemia-lymphoma, Adult T-cell | Melanoma, Malignant | Acute Anterior Uveitis | Primary Hyperoxaluria Type 1 | Hypophosphatasia | L-2-Hydroxyglutaric Aciduria | Stickler Syndrome | Angioedema, Hereditary | Myelomeningocele | Riboflavin Transporter Deficiency Neuronopathy | Dysgerminoma | Herpes Genitalis | Thyroid Hormone Resistance | Actinomycetoma | Chondrodysplasia Punctata 1, X-linked Recessive | Juvenile Polyposis | Chronic Granulomatous Disease | Dental Caries | Osteogenesis Imperfecta Type IV | Fuchs Heterochromic Iridocyclitis | Familial Male-limited Precocious Puberty | Urofacial Syndrome | 17-beta-hydroxysteroid Dehydrogenase X Deficiency | Glycogen Storage Disease Type 5 | Usher Syndrome Type II | Hereditary Pyropoikilocytosis | Pterygium | Generalized Epilepsy With Febrile Seizures Plus | Hypohidrotic Ectodermal Dysplasia, X-linked | Mucolipidosis Type IV | Pyruvate Kinase Deficiency | Hyperthyroidism | Pyruvate Dehydrogenase Deficiency | 3-methylcrotonyl-CoA Carboxylase Deficiency | Klinefelter Syndrome | Hemochromatosis Type 2 | Hairy Cell Leukemia | Cutaneous T-cell Lymphoma | Microcephaly, Seizures, And Developmental Delay | COACH Syndrome | Chronic Idiopathic Myelofibrosis | Congenital Stromal Corneal Dystrophy | Keratosis, Seborrheic | Sick Sinus Syndrome | Fibromyalgia | Leukodystrophies | Duodenal Atresia | Thyroid Dysgenesis | Anti-glomerular Basement Membrane Disease | Myelitis | Spermatocele | Temporal Lobe Epilepsy | Pneumonia, Bacterial | Occipital Neuralgia | Pneumonia, Mycoplasma | Pemphigus Foliaceus | Eosinophilia | Chediak-Higashi Syndrome | H Syndrome | Cyclic Vomiting Syndrome | Triple A Syndrome | Congenital Aniridia | Camurati-Engelmann Disease | B-cell Prolymphocytic Leukemia | Neurofibrosarcoma | Esotropia | Incontinentia Pigmenti | Proximal Symphalangism | Dyskeratosis Congenita | Meconium Ileus | Lymphopenia | Adenoma, Pleomorphic | Personality Disorders | Primary Torsion Dystonia | Tracheal Disorders | Jaundice, Obstructive | Heart Block | Hypermethioninemia | Pycnodysostosis | Sleep Disorder | Necrotizing Autoimmune Myopathy | Pneumoconiosis | Mucolipidosis Type II | Arthritis, Gouty | Uveitis | Tricho-hepato-enteric Syndrome | Pilomatrix Carcinoma | T-cell Lymphoma, Subcutaneous Panniculitis-like | Uremia | Congenital Dyserythropoietic Anemia | Aicardi-Goutieres Syndrome | Sarcoma, Endometrial Stromal | Sialidosis | Superficial Spreading Melanoma | Polycystic Ovary Syndrome | Chondrodysplasia Punctata | Chordoma | Neurofibromatosis Type 1 | Hyperacusis | Spinocerebellar Ataxia Type 20 | Retinitis Pigmentosa | Chorea-acanthocytosis | Chromosome 9q34.3 Deletion Syndrome | Glycogen Storage Disease Type 1 | Spina Bifida | Cranioectodermal Dysplasia | Muir-Torre Syndrome | Plasmacytoma | Cholelithiasis | Pseudohypoparathyroidism Type 1B | Celiac Disease | Axenfeld-Rieger Syndrome | Systemic Mastocytosis | Salla Disease | Mitochondrial DNA Depletion Syndrome 13 | Lattice Corneal Dystrophy Type 1 | Papilloma | Hyperoxaluria | Camptocormia | Fowler's Syndrome | Hyperparathyroidism | Epidermolysis Bullosa Simplex, Localized | Mood Disorder | Smith-Kingsmore Syndrome | Cataplexy | Dysfibrinogenemia | Veno-occlusive Disease | Carpal Tunnel Syndrome | Ovarian Sex Cord-stromal Tumor | 5-oxoprolinase Deficiency | Stroke | Torticollis | Osteomyelitis | FG Syndrome | Dementia, Vascular | Otopalatodigital Syndrome Type 2 | Hereditary Spherocytosis | Autosomal Recessive Spastic Paraplegia Type 35 | Norrie Disease | Absence Epilepsy | Wolfram Syndrome 2 | Werner's Syndrome | Seborrheic Dermatitis | Melnick-Needles Syndrome | Renal Oncocytoma | Transcobalamin Deficiency | Hemorrhage | Oculodentodigital Dysplasia | Aldosterone Deficiency | Hodgkin Lymphoma | Pancreatitis | Aarskog-Scott Syndrome | Early Infantile Epileptic Encephalopathy 1 | Hyper IgE Syndrome | Macular Degeneration | Asthma, Nocturnal | Glutathione Synthetase Deficiency | Fibrodysplasia Ossificans Progressiva | Meningococcal Meningitis | Chronic Myeloid Leukemia | Antithrombin III Deficiency | Endocarditis | Myoclonic Atonic Epilepsy | Corneal Dystrophy | Lymphoma | Endometrial Hyperplasia | Charcot-Marie-Tooth Disease, Type 2A | Porphyria, Variegate | Exocrine Pancreatic Insufficiency | Split Hand-foot Malformation | Pleurisy | Hypoglycemia | Chorioretinitis | Chiari Malformation Type I | Essential Fructosuria | Oculopharyngeal Muscular Dystrophy | Citrullinemia | Bronchitis, Chronic | Scleroderma, Diffuse | Lipoma | Optic Neuritis | Amyotrophic Lateral Sclerosis | Ectopia Lentis, Isolated, Autosomal Recessive | Urea Cycle Disorder | Speech Disorders | Glycogen Storage Disease Type 3 | Histiocytosis | IgA Deficiency | Congenital Tufting Enteropathy | Hypertension | Schuurs-Hoeijmakers Syndrome | Rhinitis | Metatropic Dysplasia | Von Willebrand Disease | Congenital Bilateral Absence Of Vas Deferens | Saul-Wilson Syndrome | Lymphoma Lymphoblastic | Brooke-Spiegler Syndrome | Glycogen Storage Disease Type 4 | Gerodermia Osteodysplastica | Schizoaffective Disorder | Budd-Chiari Syndrome | Hepatitis, Autoimmune | Pompe Disease | Hyperthermia, Malignant | Sarcosinemia | Acute Leukemia | Dyggve-Melchior-Clausen Disease | 6-pyruvoyl-tetrahydropterin Synthase Deficiency | Congestive Heart Failure | Retinopathy Of Prematurity | Facioscapulohumeral Muscular Dystrophy Type 1 | Ocular Surface Squamous Neoplasia | Persistent Hyperplastic Primary Vitreous | Peutz-Jeghers Syndrome | Adenosine Deaminase 2 Deficiency | Fontaine Progeroid Syndrome | Keloid | Aplastic Anemia | Hyperphenylalaninemia | Thalassemia | Kaposi Sarcoma | Dentinogenesis Imperfecta